As of version 7, CentOS fully supports only the x86-64 architecture,[162] while the following architectures are not supported:

• IA-32 in all variants, had support temporarily dropped in CentOS 7
• IA-32 without Physical Address Extension (PAE), not supported since CentOS 6
• IA-64 (Intel Itanium architecture), was supported in CentOS 3 and 4
• 32-bit PowerPC (Apple Macintosh and PowerMac running the G3 or G4 PowerPC processor), beta support was available in CentOS 4
• IBM Mainframe (eServer zSeries and S/390), not supported since CentOS 5
• Alpha, support was available in CentOS 4
• SPARC, beta support was available in CentOS 4

Tính đến tháng 12 năm 2015[cập nhật], AltArch releases of CentOS 7 are available for the ARMv7hl and AArch64 variants of the ARM architecture,[9] and plans exist for supporting other variants of the ARM architecture. ARM support is a community effort coordinated through the AltArch SIG.[9][163] AltArch releases of CentOS 7 are also available for the IA-32 architecture and Power ISA (POWER7 and POWER8 chips).[8]

A Live CD version of CentOS is available at mirror.centos.org. A bootable Live USB image of CentOS can be created manually or with UNetbootin.

CentOS images are also available on Amazon's EC2 cloud, in form of prebuilt and already published Amazon Machine Images (AMIs).[164][165]